| Nucleic acid conjugated nanomaterials for enhanced molecular recognition. | |
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MedLine Citation:
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PMID: 19658387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acids, whether designed or selected in vitro, play important roles in biosensing, medical diagnostics, and therapy. Specifically, the conjugation of functional nucleic acid based probe molecules and nanomaterials has resulted in an unprecedented improvement in the field of molecular recognition. With their unique physical and chemical properties, nanomaterials facilitate the sensing process and amplify the signal of recognition events. Thus, the coupling of nucleic acids with various nanomaterials opens up a promising future for molecular recognition. The literature offers a broad spectrum of recent advances in biosensing by employing different nanoplatforms with designed nucleic acids, especially gold nanoparticles, carbon nanotubes, silica nanoparticles, and quantum dots. The advantages of these novel combinations are discussed from the perspective of molecular recognition in chemistry, biology, and medicine, along with the problems confronting future applications. |
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Authors:
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Hao Wang; Ronghua Yang; Liu Yang; Weihong Tan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: ACS nano Volume: 3 ISSN: 1936-086X ISO Abbreviation: ACS Nano Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-22 Completed Date: 2009-12-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101313589 Medline TA: ACS Nano Country: United States |
Other Details:
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Languages: eng Pagination: 2451-60 Citation Subset: IM |
Affiliation:
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Biomedical Engineering Center, State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biosensing Techniques / methods* Humans Metal Nanoparticles / chemistry Nanostructures / chemistry* Nanotubes, Carbon / chemistry Nucleic Acids / chemistry* Quantum Dots |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM079359-01/GM/NIGMS NIH HHS; R01 GM079359-01S1/GM/NIGMS NIH HHS; R01 GM079359-02/GM/NIGMS NIH HHS; R01 GM079359-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon; 0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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