| Nucleic acid complexing glycosyl nucleoside-based amphiphile. | |
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MedLine Citation:
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PMID: 16029028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A neutral amphiphile derived from uridine featuring two oleyl chains and one glucose for DNA binding was prepared using a convenient four-step synthetic route. The nucleic acid binding capabilities of this amphiphile were investigated by UV-vis, quasi-elastic light scattering (QELS), transmission electronic microscopy (TEM), gel electrophoresis, 31P NMR, IR, and circular dichroism (CD). Amphiphile-nucleic acid complex formation is a consequence of the amphiphilic character of the molecule, phosphate-sugar, and nucleobase-nucleobase interactions. This work presents for the first time a glyco-nucleo-amphiphile capable of binding efficiently the nucleic acid double helix structure. |
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Authors:
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Jerome Arigon; Carla A H Prata; Mark W Grinstaff; Philippe Barthélémy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 16 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-07-20 Completed Date: 2005-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
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Languages: eng Pagination: 864-72 Citation Subset: IM |
Affiliation:
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Faculté des sciences d'Avignon, 33 rue Louis Pasteur, F-84000 Avignon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Electrophoresis, Agar Gel Glucose / chemistry* Microscopy, Electron, Transmission Nucleic Acid Denaturation Nucleic Acids / chemistry* Nucleosides / chemistry* Spectrum Analysis / methods |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Nucleosides; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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