| Nucleic acid-based marker approaches to urologic cancers. | |
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MedLine Citation:
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PMID: 17138133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are numerous molecular modifications known to occur in cancer. New nucleic acid-based biomarkers provide a unique approach to patient management in urologic oncology. Malignant transformation of a normal cell requires a series of epigenetic and genetic changes or "hits." Epigenetics produced by deoxyribonucleic acid methylation, adding a methyl group to the fifth position of cytosine within CpG dinucleotides, are important players in deoxyribonucleic acid repair, genome instability, and regulation of chromatin structure. Genetic alterations in cancer can include mutations, chromosome deletions, insertions, amplifications, and translocations. In addition, the modifications of telomeres are critical to the maintenance of chromatin structure, transcription, and cell function in cancer. We review only nucleic acid-based molecular biomarkers in urologic oncology that can assist the clinician in establishing the diagnosis of disease, or that can predict the behavior of the disease or the patient's survival. |
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Authors:
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Robert W Veltri; Danil V Makarov |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Urologic oncology Volume: 24 ISSN: 1078-1439 ISO Abbreviation: Urol. Oncol. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-12-01 Completed Date: 2007-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9805460 Medline TA: Urol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 510-27 Citation Subset: IM |
Affiliation:
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Department of Urology, The Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2101, USA. rveltri1@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma
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diagnosis*,
genetics* Humans Kidney Neoplasms / genetics Male Nucleic Acids / physiology* Prostatic Neoplasms / genetics Testicular Neoplasms / genetics Tumor Markers, Biological / analysis, genetics, physiology* Urinary Bladder Neoplasms / genetics Urologic Neoplasms / diagnosis*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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