| Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. | |
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MedLine Citation:
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PMID: 20031372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autoimmunity to ubiquitously expressed macromolecular nucleic acid-protein complexes such as the nucleosome or the spliceosome is a characteristic feature of systemic autoimmune diseases. Disease-specificity and/or association with clinical features of some of these autoimmune responses suggest pathogenic involvement which, however, has been proven in only a few cases so far. Although the mechanisms leading to autoimmunity against nucleic acid-containing complexes are still far from being fully understood, there is increasing experimental evidence that the nucleic acid component may act as a co-stimulator or adjuvans via activation of nucleic acid-binding receptor systems such as Toll-like receptors in antigen-presenting cells. Dysregulated apoptosis and inappropriate stimulation of nucleic acid-sensing receptors may lead to loss of tolerance against the protein components of such complexes, activation of autoreactive T cells and formation of autoantibodies. This has been demonstrated to occur in systemic lupus erythematosus and seems to represent a general mechanism that may be crucial for the development of systemic autoimmune diseases. This review provides a comprehensive overview of the most thoroughly-characterized nucleic acid-associated autoantigens, describing their structure and biological function, as well as the nature and pathogenic importance of the reactivities directed against them. Furthermore, recent advances in immunotherapy such as antigen-specific approaches targeted at nucleic acid-binding antigens are discussed. |
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Authors:
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Markus H Hoffmann; Sylvie Trembleau; Sylviane Muller; Günter Steiner |
Publication Detail:
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Type: Journal Article; Review Date: 2009-12-23 |
Journal Detail:
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Title: Journal of autoimmunity Volume: 34 ISSN: 1095-9157 ISO Abbreviation: J. Autoimmun. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: England |
Other Details:
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Languages: eng Pagination: J178-206 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Rheumatology, Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantigens / immunology*, therapeutic use Autoimmune Diseases / immunology*, therapy Humans Immunotherapy / trends Nucleoproteins / immunology*, therapeutic use Nucleosomes / genetics, immunology*, metabolism Spliceosomes / genetics, immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Autoantigens; 0/Nucleoproteins; 0/Nucleosomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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