| Nucleic acid aptamers and enzymes as sensors. | |
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MedLine Citation:
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PMID: 16678470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of nucleic acids has been an endless source of discovery and invention that has drastically enhanced our appreciation of DNA and RNA as multifaceted polymers. It is now widely known that nucleic acids can act as enzymes (deoxyribozymes and ribozymes) and as receptors (aptamers), and that these functional nucleic acids (FNAs) can either be found in nature or isolated from pools of random nucleic acids. The availability of many natural and artificial FNAs has opened a new horizon for the development of 'smart' molecules for a variety of chemical and biological applications. This review provides a snapshot of recent progress in the application of FNAs as novel sensors for biomolecular detection, drug discovery and nanotechnology. |
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Authors:
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Naveen K Navani; Yingfu Li |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-05-04 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 10 ISSN: 1367-5931 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-06 Completed Date: 2006-09-20 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 272-81 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biomedical Sciences and Department of Chemistry, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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chemistry* Base Sequence DNA / analysis Electrochemistry Enzymes / chemistry* Nucleic Acid Conformation Nucleic Acids / chemistry* Protein Denaturation Proteins / analysis RNA / analysis |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Enzymes; 0/Nucleic Acids; 0/Proteins; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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