Document Detail

Nucleic acid analogues and the origins of replication.
MedLine Citation:
PMID:  11537377     Owner:  NASA     Status:  MEDLINE    
Recent interest in the properties of "nucleic acid-like structures" has been stimulated by difficulties encountered in the synthesis and nonenzymatic oligomerization of nucleotides. However, none of the newly proposed monomers has yet been synthesized in a plausibly prebiotic manner. Arguments are presented that analogues based on 8-hydroxymethyladenine and 5-hydroxymethyluracil are promising candidates for primitive nucleotide precursors.
A W Schwartz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in space research : the official journal of the Committee on Space Research (COSPAR)     Volume:  9     ISSN:  0273-1177     ISO Abbreviation:  Adv Space Res     Publication Date:  1989  
Date Detail:
Created Date:  1995-08-08     Completed Date:  1995-08-08     Revised Date:  2007-04-16    
Medline Journal Info:
Nlm Unique ID:  9878935     Medline TA:  Adv Space Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  S    
Laboratory for Exobiology, University of Nijmegen, The Netherlands.
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MeSH Terms
Adenine / chemical synthesis*
DNA / chemistry*
Guanine / chemistry*
Hydrogen Cyanide / chemistry
Models, Chemical
Pentoxyl / analogs & derivatives,  chemical synthesis
Reg. No./Substance:
147-61-5/Pentoxyl; 4433-40-3/5-hydroxymethyluracil; 73-24-5/Adenine; 73-40-5/Guanine; 74-90-8/Hydrogen Cyanide; 9007-49-2/DNA
L E Orgel / Salk Inst for Biol Stud, San Diego, CA

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