| Nucleic acid analogues and the origins of replication. | |
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MedLine Citation:
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PMID: 11537377 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Recent interest in the properties of "nucleic acid-like structures" has been stimulated by difficulties encountered in the synthesis and nonenzymatic oligomerization of nucleotides. However, none of the newly proposed monomers has yet been synthesized in a plausibly prebiotic manner. Arguments are presented that analogues based on 8-hydroxymethyladenine and 5-hydroxymethyluracil are promising candidates for primitive nucleotide precursors. |
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Authors:
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A W Schwartz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in space research : the official journal of the Committee on Space Research (COSPAR) Volume: 9 ISSN: 0273-1177 ISO Abbreviation: Adv Space Res Publication Date: 1989 |
Date Detail:
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Created Date: 1995-08-08 Completed Date: 1995-08-08 Revised Date: 2007-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9878935 Medline TA: Adv Space Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: S |
Affiliation:
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Laboratory for Exobiology, University of Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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chemical synthesis* Biogenesis* DNA / chemistry* Guanine / chemistry* Hydrogen Cyanide / chemistry Models, Chemical Pentoxyl / analogs & derivatives, chemical synthesis |
| Chemical | |
Reg. No./Substance:
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147-61-5/Pentoxyl; 4433-40-3/5-hydroxymethyluracil; 73-24-5/Adenine; 73-40-5/Guanine; 74-90-8/Hydrogen Cyanide; 9007-49-2/DNA |
| Investigator | |
Investigator/Affiliation:
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L E Orgel / Salk Inst for Biol Stud, San Diego, CA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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