| Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone. | |
| | |
MedLine Citation:
|
PMID: 20087996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Starting from pyranose nucleic acids, several series of modified nucleic acids with a six-membered carbohydrate moiety (mimic) have been synthesized and analyzed over a period of 20 years, and this work is summarized here. The process starts with structural and conformational considerations, followed by synthetic efforts and a structural analysis, and ends up with a biological confirmation of the concept, demonstrating that these modified nucleic acids represent very valuable tools in chemistry and biology. |
| | |
Authors:
|
Piet Herdewijn |
Related Documents
:
|
4330316 - Characterization of a heat-shock process for reduction of the nucleic acid content of c... 212106 - Nucleic acid interaction with vero cells. a temperature barrier in the interaction patt... 15294076 - Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology. 8643586 - Extremely sensitive, background-free gene detection using binary probes and beta replic... 16001866 - Chromatographic determination of amino acids in foods. 3867236 - Acid instillation increases gastric luminal prostaglandin e2 output in man. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Chemistry & biodiversity Volume: 7 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-26 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 1-59 Citation Subset: IM |
Affiliation:
|
Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven. Piet.Herdewijn@rega.kuleuven.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbohydrates
/
chemistry* Cyclohexanes / chemistry Cyclohexenes / chemistry Mannitol / chemistry Molecular Conformation Nucleic Acids / chemistry* Sugar Alcohols / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Carbohydrates; 0/Cyclohexane; 0/Cyclohexanes; 0/Cyclohexenes; 0/Nucleic Acids; 0/Sugar Alcohols; 0/hexitol; 110-83-8/cyclohexene; 5552-13-6/altritol; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Who Is the King? The alpha-Hydroxy-beta-oxo-alpha,beta-enone Moiety or the Catechol B Ring: Relation...
Next Document: Crystallographic studies of chemically modified nucleic acids: a backward glance.