| Nucleic acid detection using MNAzymes. | |
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MedLine Citation:
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PMID: 20189100 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics. |
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Authors:
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Yulia V Gerasimova; Dmitry M Kolpashchikov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry & biology Volume: 17 ISSN: 1879-1301 ISO Abbreviation: Chem. Biol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-06-08 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 9500160 Medline TA: Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 104-6 Citation Subset: - |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of Central Florida, Orlando, FL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R21 HG004060-03/HG/NHGRI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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