Document Detail


Nucleic Acid Carriers Based on Precise Polymer Conjugates.
MedLine Citation:
PMID:  21749135     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polymer polydispersity, random conjugation of functional groups and poorly understood structure activity relationships have constantly hampered the progress in the development of nucleic acid carriers. This review focuses on the synthetic concepts for generation of precise polymers, site-specific conjugation strategies and multifunctional conjugates for nucleic acid transport. Dendrimers, defined peptide carriers, sequence-defined polyamidoamines assembled by solid-phase supported synthesis, and precise lipopeptides or lipopolymers have been characterized for pDNA and siRNA delivery. Conjugation techniques like click chemistries and peptide ligation are available for conjugating polymers with functional transport elements such as targeting or shielding domains, and for direct covalent modification of therapeutic nucleic acids in a site-specific mode.
Authors:
Christina Troiber; Ernst Wagner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-13
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  -     ISSN:  1520-4812     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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