| Nucleic Acid-Based Therapeutics For Glioblastoma. | |
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MedLine Citation:
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PMID: 21707501 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Nucleic acid based therapeutics offer the possibility for tailor made treatment of malignant diseases. For glioblastoma multiforme (GBM), the most aggressive type of brain tumor, no standard treatment exists for recurrent disease making therapeutically active nucleic acids a vital option. Within this review current preclinical and clinical studies harnessing the potential of antitumoral nucleic acids for GBM treatment will be reviewed. This includes gene therapy approaches for over-expression of antitumoral gene products, the application of RNA interference technology to knockdown component which otherwise promote tumor progression and the tumor targeted delivery of antitumoral double stranded RNA. Delivery vector for nucleic acids applied in GBM treatment will be discussed including non-replicating and replicating (oncolytic) viruses and also non-viral delivery vectors based on polycations or cationic lipids. |
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Authors:
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Alexei Shir; Alexander Levitzki; Ernst Wagner; Manfred Ogris |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-27 |
Journal Detail:
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Title: Anti-cancer agents in medicinal chemistry Volume: - ISSN: 1875-5992 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265649 Medline TA: Anticancer Agents Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Unit of Cellular Signaling, Department of Biological Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, Israel. alexeis@cc.huji.ac.il. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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