Document Detail


Nucleated red blood cell counts and erythropoietin levels in high-risk neonates.
MedLine Citation:
PMID:  12421253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The presence of increased numbers of nucleated red blood cells (NRBC) and increased levels of erythropoietin (EPO) in the circulation of neonates has been associated with states of relative hypoxia. The aim of this study is to assess the pattern of NRBC counts and EPO levels in a group of high-risk neonates under stress conditions and determine the short-term outcome for these babies by using these parameters. METHODS: There were 69 high-risk neonates; 14 intrauterine growth retarded (IUGR), 25 preterm infants, 18 term infants with asphyxia and 12 infants of diabetic mothers. Control groups included healthy, term infants delivered either vaginally (n = 18) or with cesarean section (n = 19). Three blood samples were obtained from each infant within 12 h (initial), 3 days and 7 days after birth to measure NRBC counts and EPO levels. Neonatal and short-term outcomes at 3 and 6 months of age were determined. RESULTS: There was no significant difference among the groups with regard to the initial serum EPO concentrations. The initial NRBC counts were significantly lower in the control groups compared with the study groups (P = 0.002). While there was no significant difference between patients with good and poor outcome in terms of EPO concentrations of initial samples, a significant difference existed in terms of NRBC counts (P = 0.038). CONCLUSIONS: Both serum EPO level and NRBC count provide limited clinical benefit in the detection of pathological conditions of the neonatal period, but NRBC count determination seems to be especially helpful in predicting short-term neurodevelopmental outcome.
Authors:
Ulfet Vatansever; Betül Acunaş; Muzaffer Demir; Serap Karasalihoglu; Galip Ekuklu; Seralp Ener; Ozer Pala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  44     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-02-26     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  590-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Faculty of Medicine, Trakya University, Edirne, Turkey. u_vatansever@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anoxia / blood*
Erythroblasts*
Erythrocyte Count / methods
Erythropoietin / analysis*
Female
Humans
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature / blood*
Male
Prospective Studies
Chemical
Reg. No./Substance:
11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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