Document Detail

Nucleated red blood cell count and doppler ultrasound in low- and high-risk pregnancies.
MedLine Citation:
PMID:  10968339     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to evaluate the influence of circulatory deterioration in small-for-gestational-age fetuses (SGA) on the nucleated red blood cell count (NRBC). PATIENTS AND METHODS: During a 12-month period 194 patients with a complete NRBC count post-partum were enrolled in the study. Using pulsed wave colour Doppler ultrasound we recorded blood flow velocity waveforms from both uterine arteries and from the umbilical artery and/or from the fetal aorta. Patients were assigned to seven groups according to the results of the Doppler examination. Mean outcome measures were birthweight, gestational age at delivery, NRBC count, incidence of preeclampsia or SGA and need of neonatal intensive care. RESULTS: Significantly higher nucleated red blood cell counts than in all other groups were found in cases with abnormal Doppler findings in both uterine arteries and the umbilical artery and/or fetal aorta (p<0.001). These newborns had significantly lower birth weights (p<0.01, p<0.001), lower gestational age (p<0.001), an increased likelihood of caesarean section for clinical signs of fetal distress (p<0.001) and had to be transfered more frequently to the neonatal intensive care unit (p<0.01, p<0.001). CONCLUSION: Patients with abnormal Doppler velocimetry waveforms of the uterine arteries in the presence of an abnormal umbilical artery or fetal aorta Doppler findings have a high risk of prematurity, preeclampsia or delivering a small-for-gestational-age newborn. Fetal response to uteroplacental insufficiency may lead to elevated nucleated red blood cells in the fetal blood. This fact might help to discriminate the small-for-gestational-age fetus who is growth-retarded and suffers from chronic placental insufficiency from the small but healthy fetus.
R Axt-Fliedner; M Wrobel; H J Hendrik; A K Ertan; D Mink; J König; W Schmidt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  27     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-06     Completed Date:  2001-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of the Saarland, Homberg/Saar, Germany.
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MeSH Terms
Birth Weight
Blood Flow Velocity
Erythrocyte Count
Fetal Blood
Fetal Growth Retardation / blood,  physiopathology,  ultrasonography
Infant, Newborn
Infant, Small for Gestational Age*
Pre-Eclampsia / blood,  physiopathology,  ultrasonography
Pregnancy / physiology*
Pregnancy Complications / blood*,  physiopathology*,  ultrasonography
Pregnancy Outcome
Prospective Studies
Ultrasonography, Doppler, Color
Ultrasonography, Prenatal*
Umbilical Arteries / physiology
Uterus / blood supply*

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