Document Detail

Nucleated red blood cell count at birth as an index of perinatal brain damage.
MedLine Citation:
PMID:  10601935     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The prognostic value of the nucleated red blood cell count at birth with respect to perinatal brain damage and neonatal outcome was assessed in infants at high risk of having neurologic damage. STUDY DESIGN: The nucleated red blood cell count at birth, pulsed Doppler ultrasonography in the cerebral arteries, cranial fontanelle sonograms, and neurodevelopmental status were evaluated in 337 newborn infants. RESULTS: The nucleated red blood cell count at birth was significantly higher (1) in neonates with abnormal Doppler ultrasonographic parameters for the cerebral arteries at 48 to 72 hours after birth than in healthy neonates, (2) in 6-month-old infants with sequelae of hypoxic-ischemic encephalopathy than in healthy infants, and (3) in 3-year-old children with abnormal developmental status than in those with no abnormalities at follow-up. Significant correlations were observed between the nucleated red blood cell count and gestational age, Apgar score at 1 and 5 minutes, pH, base deficit, fraction of inspired oxygen, blood oxygen content, and birth weight. CONCLUSIONS: The nucleated red blood cell count at birth not only reflects a response of the infant to perinatal hypoxia but is also a reliable index of perinatal brain damage.
G Buonocore; S Perrone; D Gioia; M G Gatti; C Massafra; R Agosta; R Bracci
Related Documents :
8242725 - Dopamine d2-receptor imaging with 123i-iodobenzamide spect in migraine patients abusing...
19710635 - Adult attachment predicts maternal brain and oxytocin response to infant cues.
10416995 - Case of the month: january 1999--fetus with echogenic mass in third ventricle.
3508695 - Pseudotumor cerebri associated with obstructive nephropathy.
17489475 - Expanded health data from the new birth certificate, 2004.
18952015 - Bipedalism and parturition: an evolutionary imperative for cesarean delivery?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  181     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1500-5     Citation Subset:  AIM; IM    
Institute of Preventive Paediatrics and Neonatology, University of Siena, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / blood*
Apgar Score
Brain Injuries / blood,  diagnosis*,  ultrasonography
Case-Control Studies
Cerebral Arteries / ultrasonography*
Developmental Disabilities / diagnosis*
Erythroblasts / pathology*
Erythrocyte Count
Heart Rate, Fetal
Infant, Newborn
Infant, Premature, Diseases / blood,  diagnosis,  ultrasonography
Predictive Value of Tests
Ultrasonography, Doppler, Pulsed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A randomized clinical trial of daily nonstress testing versus biophysical profile in the management ...
Next Document:  A randomized, controlled trial of a eutectic mixture of local anesthetic cream (lidocaine and priloc...