Document Detail


Nucleated red blood cell count at birth as an index of perinatal brain damage.
MedLine Citation:
PMID:  10601935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The prognostic value of the nucleated red blood cell count at birth with respect to perinatal brain damage and neonatal outcome was assessed in infants at high risk of having neurologic damage. STUDY DESIGN: The nucleated red blood cell count at birth, pulsed Doppler ultrasonography in the cerebral arteries, cranial fontanelle sonograms, and neurodevelopmental status were evaluated in 337 newborn infants. RESULTS: The nucleated red blood cell count at birth was significantly higher (1) in neonates with abnormal Doppler ultrasonographic parameters for the cerebral arteries at 48 to 72 hours after birth than in healthy neonates, (2) in 6-month-old infants with sequelae of hypoxic-ischemic encephalopathy than in healthy infants, and (3) in 3-year-old children with abnormal developmental status than in those with no abnormalities at follow-up. Significant correlations were observed between the nucleated red blood cell count and gestational age, Apgar score at 1 and 5 minutes, pH, base deficit, fraction of inspired oxygen, blood oxygen content, and birth weight. CONCLUSIONS: The nucleated red blood cell count at birth not only reflects a response of the infant to perinatal hypoxia but is also a reliable index of perinatal brain damage.
Authors:
G Buonocore; S Perrone; D Gioia; M G Gatti; C Massafra; R Agosta; R Bracci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  181     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-20     Completed Date:  2000-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1500-5     Citation Subset:  AIM; IM    
Affiliation:
Institute of Preventive Paediatrics and Neonatology, University of Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Anoxia / blood*
Apgar Score
Brain Injuries / blood,  diagnosis*,  ultrasonography
Case-Control Studies
Cerebral Arteries / ultrasonography*
Developmental Disabilities / diagnosis*
Erythroblasts / pathology*
Erythrocyte Count
Female
Heart Rate, Fetal
Humans
Infant, Newborn
Infant, Premature, Diseases / blood,  diagnosis,  ultrasonography
Male
Predictive Value of Tests
Pregnancy
Prognosis
Ultrasonography, Doppler, Pulsed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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