Document Detail

Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development.
MedLine Citation:
PMID:  21504779     Owner:  NLM     Status:  Publisher    
The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through the activation of cognate nuclear receptors, RARs, which work as ligand dependent regulators of transcription. In vitro studies revealed how RARs control gene expression at the molecular level and now it appears that it is fine-tuned by a phosphorylation code. In addition, several genetic approaches provided valuable insights on the functions of RARs during development and on the influence of other actors such as the enzymes involved in RA synthesis and degradation and other signaling pathways. It appears that RARs are the conductors of the RA signaling symphony through controlling the dynamics and the coordination of the different players and development steps.
Eric Samarut; Cécile Rochette-Egly
Related Documents :
21405069 - Self-assembly, foaming, and emulsifying properties of sodium alkyl carboxylate/guanidin...
9626489 - The thiobarbituric acid (tba) reaction in foods: a review.
21213029 - Synthesis of ethynylated phenothiazine based fluorescent boronic acid probes.
2742859 - Nonesterified fatty acids inhibit iron-dependent lipid peroxidation.
21216009 - Distribution of naphthenic acids in tissues of laboratory-exposed fish and in wild fish...
21212879 - Borate esters as convenient reagents for direct amidation of carboxylic acids and trans...
5660639 - Studies on the enzymic n-acylation of amino sugars in the sheep colonic mucosa.
7746489 - A study of the uptake of glutamate, gamma-aminobutyric acid (gaba), glycine and beta-al...
10366139 - Knowledge and use of folic acid by women of childbearing age--united states, 1995 and 1...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  -     ISSN:  1872-8057     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), INSERM, U596; CNRS, UMR7104; Université de Strasbourg, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Morphological analysis of proximal contacts in class II direct restorations with 3D image reconstruc...
Next Document:  Purified high molecular weight synthetic A?(1-42) and biological A? oligomers are equipotent in rapi...