| Nuclear reprogramming in cells. | |
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MedLine Citation:
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PMID: 19095934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research. |
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Authors:
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J B Gurdon; D A Melton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 322 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1811-5 Citation Subset: IM |
Affiliation:
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Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 12N, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Dedifferentiation Cell Differentiation Cell Fusion Cell Lineage Cloning, Organism DNA / metabolism DNA-Binding Proteins / metabolism Embryonic Stem Cells / cytology, physiology Female Gene Expression Humans Male Nuclear Reprogramming* Nuclear Transfer Techniques Oocytes / cytology Pluripotent Stem Cells / cytology, physiology Regulatory Sequences, Nucleic Acid Transcription Factors / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Transcription Factors; 9007-49-2/DNA |
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