Document Detail

Nuclear reprogramming in cells.
MedLine Citation:
PMID:  19095934     Owner:  NLM     Status:  MEDLINE    
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these methods it becomes possible to derive one kind of specialized cell (such as a brain cell) from another, more accessible, tissue (such as skin) in the same individual. This has potential applications for cell replacement without the immunosuppression treatments that are required when cells are transferred between genetically different individuals. This article provides some background to this field, a discussion of mechanisms and efficiency, and comments on prospects for future nuclear reprogramming research.
J B Gurdon; D A Melton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  322     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1811-5     Citation Subset:  IM    
Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 12N, UK.
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MeSH Terms
Cell Dedifferentiation
Cell Differentiation
Cell Fusion
Cell Lineage
Cloning, Organism
DNA / metabolism
DNA-Binding Proteins / metabolism
Embryonic Stem Cells / cytology,  physiology
Gene Expression
Nuclear Reprogramming*
Nuclear Transfer Techniques
Oocytes / cytology
Pluripotent Stem Cells / cytology,  physiology
Regulatory Sequences, Nucleic Acid
Transcription Factors / genetics,  metabolism
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Transcription Factors; 9007-49-2/DNA

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