Document Detail


Nuclear receptors in bile acid metabolism.
MedLine Citation:
PMID:  23330546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bile acids are signaling molecules that activate nuclear receptors, such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor, and play a critical role in the regulation of lipid, glucose, energy, and drug metabolism. These xenobiotic/endobiotic-sensing nuclear receptors regulate phase I oxidation, phase II conjugation, and phase III transport in bile acid and drug metabolism in the digestive system. Integration of bile acid metabolism with drug metabolism controls absorption, transport, and metabolism of nutrients and drugs to maintain metabolic homeostasis and also protects against liver injury, inflammation, and related metabolic diseases, such as nonalcoholic fatty liver disease, diabetes, and obesity. Bile-acid-based drugs targeting nuclear receptors are in clinical trials for treating cholestatic liver diseases and fatty liver disease.
Authors:
Tiangang Li; John Y L Chiang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Drug metabolism reviews     Volume:  45     ISSN:  1097-9883     ISO Abbreviation:  Drug Metab. Rev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-16     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0322067     Medline TA:  Drug Metab Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  145-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / metabolism*
Biological Transport
Humans
Metabolic Detoxication, Drug
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism*
Xenobiotics / metabolism,  pharmacology
Grant Support
ID/Acronym/Agency:
DK44442/DK/NIDDK NIH HHS; DK58379/DK/NIDDK NIH HHS; R01 DK044442/DK/NIDDK NIH HHS; R56 DK044442/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Receptors, Cytoplasmic and Nuclear; 0/Xenobiotics
Comments/Corrections

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