| Nuclear receptors in bile acid metabolism. | |
| | |
MedLine Citation:
|
PMID: 23330546 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Bile acids are signaling molecules that activate nuclear receptors, such as farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, and vitamin D receptor, and play a critical role in the regulation of lipid, glucose, energy, and drug metabolism. These xenobiotic/endobiotic-sensing nuclear receptors regulate phase I oxidation, phase II conjugation, and phase III transport in bile acid and drug metabolism in the digestive system. Integration of bile acid metabolism with drug metabolism controls absorption, transport, and metabolism of nutrients and drugs to maintain metabolic homeostasis and also protects against liver injury, inflammation, and related metabolic diseases, such as nonalcoholic fatty liver disease, diabetes, and obesity. Bile-acid-based drugs targeting nuclear receptors are in clinical trials for treating cholestatic liver diseases and fatty liver disease. |
| | |
Authors:
|
Tiangang Li; John Y L Chiang |
Related Documents
:
|
20840626 - A new species of hagfish (myxinidae: eptatretus) from papua new guinea. 21652106 - Microbial physiology-based model of ethanol metabolism in subsurface sediments. 15078536 - Methionine catabolism and production of volatile sulphur compounds by oenococcus oeni. 7895616 - Identification of hepatocytes as the major locus of 2,3,7,8-tetrachlorodibenzo-p-dioxin... 12418016 - Mechanical properties of coagulated albumin and failure mechanisms of liver repaired wi... 3641786 - Failure of guinea pig plasma kallikrein to cause neutrophil migration. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drug metabolism reviews Volume: 45 ISSN: 1097-9883 ISO Abbreviation: Drug Metab. Rev. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0322067 Medline TA: Drug Metab Rev Country: England |
Other Details:
|
Languages: eng Pagination: 145-55 Citation Subset: IM |
Affiliation:
|
Department of Integrative Medical Sciences, Northeast Ohio Medical University , Rootstown, Ohio , USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nuclear receptors in the cross-talk of drug metabolism and inflammation.
Next Document: Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the end...