Document Detail

Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.
MedLine Citation:
PMID:  23355206     Owner:  NLM     Status:  In-Data-Review    
Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM.
Mark J Roberts; Amy Chadburn; Shuo Ma; Elizabeth Hyjek; Loann C Peterson
Related Documents :
24336796 - Rasgrp1 mutation increases naive t-cell cd44 expression and drives mtor-dependent accum...
24122226 - Over-expression of cxcr4 on mesenchymal stem cells protect against experimental colitis...
24804546 - Highly specific targeting of human leukocytes using gold nanoparticle-based biologicall...
23524976 - Elevated granzyme b in cytotoxic lymphocytes is a signature of immune activation in hem...
17142846 - Human embryonic stem cells: an in vitro model to study mechanisms controlling pluripote...
94306 - Studies of the producer cell of interferon in human lymphocyte cultures.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  139     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-9     Citation Subset:  AIM; IM    
Dept of Pathology, Northwestern University-Feinberg School of Medicine, 251 E. Huron, Feinberg 7-212, Chicago, IL 60611;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Establishment of a CYP2C19 Genotyping Assay for Clinical Use.
Next Document:  Immunohistochemical Detection of Hairy Cell Leukemia in Paraffin Sections Using a Highly Effective C...