Document Detail


Nuclear overexpression of the E2F3 transcription factor in human lung cancer.
MedLine Citation:
PMID:  16938365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The E2F3 transcription factor has an established role in controlling cell cycle progression. In previous studies we have provided evidence that nuclear E2F3 overexpression represents a mechanism that drives the development of human bladder cancer and that determines aggressiveness in human prostate cancer. We have proposed a model in which E2F3 overexpression co-operates with removal of the E2F inhibitor pRB to facilitate cancer development. Since small cell lung cancers (SCLC) have one of the highest reported frequencies of functional abnormalities in the pRB protein (90%) of any human cancer, we wish to assess to what extent E2F3 would be overexpressed in this and other classes of human lung cancer. METHODS: Immunohistochemical techniques were used to assess the E2F3 status in 428 samples of lung cancers, lung carcinoids, normal bronchial epithelium and normal lung tissue. RESULTS: E2F3 is overexpressed in 55-70% of squamous cell carcinomas and 79% of adenocarcinomas of the lung. In addition very high level expression of nuclear E2F3 is found in almost all small cell lung cancers analysed. When considered together with published data our observations indicate that co-operation between pRB functional knockouts and E2F3 overexpression may represent a mechanism of development of SCLC.
Authors:
Colin S Cooper; Andrew G Nicholson; Christopher Foster; Andrew Dodson; Sandra Edwards; Anne Fletcher; Toby Roe; Jeremy Clark; Anupam Joshi; Andrew Norman; Andrew Feber; Dongmei Lin; Yanning Gao; Janet Shipley; Shu-Jun Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-30
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  54     ISSN:  0169-5002     ISO Abbreviation:  Lung Cancer     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Affiliation:
Section of Molecular Carcinogenesis, Male Urological Cancer Research Centre, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. colin.cooper@icr.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics,  metabolism*,  pathology
Carcinoid Tumor / genetics,  metabolism,  pathology
Carcinoma, Neuroendocrine / genetics,  metabolism,  pathology
Carcinoma, Small Cell / genetics,  metabolism,  pathology
Carcinoma, Squamous Cell / genetics,  metabolism,  pathology
Cell Nucleus / metabolism
E2F3 Transcription Factor / genetics,  metabolism*
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Humans
Immunohistochemistry
Lung Neoplasms / genetics,  metabolism*,  pathology
Oligonucleotide Array Sequence Analysis
Chemical
Reg. No./Substance:
0/E2F3 Transcription Factor; 0/E2F3 protein, human

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