Document Detail


Nuclear organization of cholinergic, putative catecholaminergic and serotonergic systems in the brains of five microchiropteran species.
MedLine Citation:
PMID:  20566329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current study describes, using immunohistochemical methods, the nuclear organization of the cholinergic, catecholaminergic and serotonergic systems within the brains of five microchiropteran species. For the vast majority of nuclei observed, direct homologies are evident in other mammalian species; however, there were several distinctions in the presence or absence of specific nuclei that provide important clues regarding the use of the brain in the analysis of chiropteran phylogenetic affinities. Within the five species studied, three specific differences (presence of a parabigeminal nucleus, dorsal caudal nucleus of the ventral tegmental area and the absence of the substantia nigra ventral) found in two species from two different families (Cardioderma cor; Megadermatidae, and Coleura afra; Emballonuridae), illustrates the diversity of microchiropteran phylogeny and the usefulness of brain characters in phylogenetic reconstruction. A number of distinct differences separate the microchiropterans from the megachiropterans, supporting the diphyletic hypothesis of chiropteran phylogenetic origins. These differences phylogenetically align the microchiropterans with the heterogenous grouping of insectivores, in contrast to the alignment of megachiropterans with primates. The consistency of the changes and stasis of neural characters with mammalian phylogeny indicate that the investigation of the microchiropterans as a sister group to one of the five orders of insectivores to be a potentially fruitful area of future research.
Authors:
Jean-Leigh Kruger; Leigh-Anne Dell; Adhil Bhagwandin; Ngalla E Jillani; John D Pettigrew; Paul R Manger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-04
Journal Detail:
Title:  Journal of chemical neuroanatomy     Volume:  40     ISSN:  1873-6300     ISO Abbreviation:  J. Chem. Neuroanat.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902615     Medline TA:  J Chem Neuroanat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  210-22     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Affiliation:
School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / anatomy & histology*,  metabolism
Catecholamines / metabolism
Chiroptera / anatomy & histology*,  metabolism
Immunohistochemistry
Serotonin / metabolism
Chemical
Reg. No./Substance:
0/Catecholamines; 50-67-9/Serotonin

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