| Nuclear morphology in breast cancer: is pleomorphism an illusion? | |
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MedLine Citation:
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PMID: 11021321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nuclear pleomorphism is an underlying theme of cancer histology. Any medical practitioner, not just the pathologist, would have at one time or another in a Pathology practical class, looked at histopathology slides and convinced himself or herself that cancer cells indeed looked more variable in size and shape than nontumorigenic cells. However, data from our nuclear morphometric analysis of cells in breast cancer and adjacent benign tissues appears to suggest that the larger size of the cancer cell nuclei could make any change in nuclear shape and size more noticeable and apparent than their benign counterparts. We hypothesize that the phenomenon of nuclear pleomorphism is due partly to observational subjectivity. |
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Authors:
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J Huang; B H Bay; P H Tan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical hypotheses Volume: 55 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2001-01-17 Completed Date: 2001-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 26-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy, National University of Singapore, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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pathology*,
ultrastructure Cell Nucleus / pathology*, ultrastructure Female Humans Models, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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