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Nuclear medicine in cerebrovascular disease.
MedLine Citation:
PMID:  23026361     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Stroke and cerebrovascular diseases are major causes of mortality, morbidity, and disability. Nuclear Medicine, primarily via tomographic methods, has made significant contributions to the understanding of the hemodynamic and metabolic consequences of cerebrovascular diseases. In this review, the findings in acute, subacute, and chronic cerebrovascular diseases are described. Many of the pathophysiologic processes and consequences that follow stroke, including completed infarct core, adjacent penumbra, and diaschisis, have been investigated with Nuclear Medicine, and stroke outcome may be related to these phenomena. Additional topics included in this review are cerebrovascular reserve tests and multi-infarct dementia. Finally, Nuclear Medicine investigations of stroke recovery and cerebral plasticity appear to indicate that enhanced activity of preexisting networks, rather than substitution of function, represents the most important mechanism of improvement in chronic stroke rehabilitation.
Authors:
David H Lewis; Lauren K Toney; Jean-Claude Baron
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in nuclear medicine     Volume:  42     ISSN:  1558-4623     ISO Abbreviation:  Semin Nucl Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1264464     Medline TA:  Semin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-405     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Division of Nuclear Medicine, Department of Radiology, University of Washington School of Medicine, Seattle, WA. Electronic address: lewis@uw.edu.
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