| Nuclear mechanisms of hypoxic cerebral injury in the newborn: the role of caspases. | |
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MedLine Citation:
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PMID: 18929156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our laboratory has been actively engaged in investigating mechanisms of activation of initiator caspase-9 during hypoxia in the developing newborn and fetal brains. The present review has been organized as follows: (a) the effect of hypoxia on the expression and activation of caspase-3, -8, and -9 in the newborn brain; (b) the role of nitric oxide in caspase-9, and caspase-3 activation during hypoxia in the newborn brain; (c) the role of nuclear Ca(2+)-influx in caspase-9 and caspase-3 activation during hypoxia in the newborn brain; (d) the effect of caspase-9 inhibition during hypoxia on preventing downstream events including caspase-3 activation. The results of our research investigations presented in (b), (c), and (d) elucidate mechanisms of caspase activation during hypoxia in the newborn brain. These studies provide the fundamental framework for developing neuroprotective strategies in the hypoxic newborn. |
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Authors:
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Maria Delivoria-Papadopoulos; Qazi M Ashraf; Jahan Ara; Om P Mishra |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 32 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 334-43 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, PA 19102, USA. papadopoulos@DrexelMed.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Brain / enzymology Caspase 3 / physiology Caspase 8 / physiology Caspase 9 / physiology Caspases / physiology* Enzyme Activation Humans Hypoxia, Brain / enzymology* Infant, Newborn Models, Animal Nitric Oxide / physiology Swine |
| Grant Support | |
ID/Acronym/Agency:
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NIH-HD-R01 38079/HD/NICHD NIH HHS; NIH-HD-R01 20337/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
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