Document Detail


Nuclear mechanisms of hypoxic cerebral injury in the newborn: the role of caspases.
MedLine Citation:
PMID:  18929156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our laboratory has been actively engaged in investigating mechanisms of activation of initiator caspase-9 during hypoxia in the developing newborn and fetal brains. The present review has been organized as follows: (a) the effect of hypoxia on the expression and activation of caspase-3, -8, and -9 in the newborn brain; (b) the role of nitric oxide in caspase-9, and caspase-3 activation during hypoxia in the newborn brain; (c) the role of nuclear Ca(2+)-influx in caspase-9 and caspase-3 activation during hypoxia in the newborn brain; (d) the effect of caspase-9 inhibition during hypoxia on preventing downstream events including caspase-3 activation. The results of our research investigations presented in (b), (c), and (d) elucidate mechanisms of caspase activation during hypoxia in the newborn brain. These studies provide the fundamental framework for developing neuroprotective strategies in the hypoxic newborn.
Authors:
Maria Delivoria-Papadopoulos; Qazi M Ashraf; Jahan Ara; Om P Mishra
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  32     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  334-43     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Drexel University College of Medicine and St Christopher's Hospital for Children, Philadelphia, PA 19102, USA. papadopoulos@DrexelMed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Brain / enzymology
Caspase 3 / physiology
Caspase 8 / physiology
Caspase 9 / physiology
Caspases / physiology*
Enzyme Activation
Humans
Hypoxia, Brain / enzymology*
Infant, Newborn
Models, Animal
Nitric Oxide / physiology
Swine
Grant Support
ID/Acronym/Agency:
NIH-HD-R01 38079/HD/NICHD NIH HHS; NIH-HD-R01 20337/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases

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