| Nuclear matrix protein levels in burn patients with multiple organ dysfunction syndrome. | |
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MedLine Citation:
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PMID: 10630850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we investigated multiple organ dysfunction syndrome (MODS) and nuclear matrix protein (NMP), which is an indicator for apoptosis, in burn patients. The subjects were 17 patients with a total burn surface area (TBSA) of 26% or more. Eight of them had MODS, and nine did not. Seven patients died, and 10 survived. The NMP value in the group with MODS (610 +/- 318 units/ml) was significantly higher than in the group without MODS (82 +/- 31 units/ml). The NMP values of the patients who died (645 +/- 326 units/ml) were significantly higher than in the group who survived (111 +/- 95 units/ml), and they rose significantly as the number of impaired organs increased. Our findings suggested that the NMP level in burn cases associated with MODS was higher when apoptosis developed and larger numbers of organs were impaired. |
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Authors:
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Y Yamada; S Endo; H Nakae; Y Kamei; S Taniguchi; H Ishikura; T Tanaka; K Taki; K Inada |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 25 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-04 Completed Date: 2000-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 705-8 Citation Subset: IM |
Affiliation:
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Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Nuclear Apoptosis Biological Markers / blood Burns, Inhalation / blood*, complications, pathology Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Multiple Organ Failure / blood*, etiology, mortality Nitric Oxide / blood Nuclear Proteins / blood* Prognosis Survival Rate Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Nuclear; 0/Biological Markers; 0/Nuclear Proteins; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide |
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