| Nuclear magnetic resonance spectroscopy to determine the micellar cholesterol in human bile. | |
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MedLine Citation:
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PMID: 1547885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cholesterol of gallstones comes from the vesicular rather than the micellar phase of bile. Progress in this field has been limited because conventional analytical methods disturb the distribution of cholesterol between the two phases. The resonance of the cholesterol C6 proton occurs at a chemical shift of 5.4 ppm, to be shown by 2D NMR to be specific for biliary cholesterol, and arises only from the micellar mode. Thus integration of the C6 proton resonance peak area provides a direct non-invasive determination of the cholesterol distribution in human bile. |
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Authors:
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J P Ellul; G M Murphy; H G Parkes; R Z Slapa; R H Dowling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 300 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-04-20 Completed Date: 1992-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 30-2 Citation Subset: IM |
Affiliation:
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Gastroenterology Unit, United Medical School of Guy's Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile
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chemistry* Cholesterol / chemistry* Humans Magnetic Resonance Spectroscopy Micelles* |
| Chemical | |
Reg. No./Substance:
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0/Micelles; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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