Document Detail


Nuclear magnetic resonance Hahn spin-echo decay (T2) in live rats with endotoxin lung injury.
MedLine Citation:
PMID:  8464359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the possibility of using nuclear magnetic resonance imaging to study experimentally induced lung injury, we measured in the lungs of spontaneously breathing living rats the time course of both the Hahn spin-echo decay (T2) and the proton density after endotoxin injury. In order to minimize artifacts arising from motions of the nearby chest wall and heart, we used a motion-insensitive technique (the interleaved line scan). A typical Hahn T2 measurement was obtained over a region of interest from a series of images each with a different echo time, which ranged from 16 to 110 ms. Lung water content was determined by integrating the proton density over the region of interest. The Hahn T2 and proton density were measured before and at 1, 3, 6, and 9 h after intravenous injection of endotoxin. The effects of the treatment administered before and after endotoxin injection were also evaluated. Endotoxin treatment caused lengthening of both fast (T2f) and slow (T2s) Hahn T2 components but had no significant effect on the proton density, consistent with the notion that endotoxin causes lung injury without significant lung water accumulation in rats. However, the methylprednisolone treatment prevented the lengthening of T2s but did not seem to have a significant effect on T2f. Our results suggest that NMR imaging can be used to detect and monitor experimental lung injury in intact living animals, even in the absence of variations of lung water content.
Authors:
S Shioya; R Christman; D C Ailion; A G Cutillo; K C Goodrich
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  29     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  IM    
Affiliation:
Department of Physics, University of Utah, Salt Lake City 84112.
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MeSH Terms
Descriptor/Qualifier:
Animals
Endotoxins / adverse effects*
Escherichia coli Infections / diagnosis*,  drug therapy
Female
Magnetic Resonance Imaging / methods*
Methylprednisolone / therapeutic use
Pulmonary Edema / diagnosis,  drug therapy,  microbiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
CA44972/CA/NCI NIH HHS; HL31216/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endotoxins; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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