| Nuclear location of synthetic oligonucleotides microinjected somatic cells: its implication in an antisense strategy. | |
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MedLine Citation:
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PMID: 1668686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthetic oligonucleotides are widely used to modulate gene expression. However their development as genetic tools and as molecule of therapeutic interest is restricted by the poor knowledge of their mechanism of action and of their uptake by cells. We recently found that microinjected oligonucleotides accumulates in the nucleus of the cells. These observations are described and their implications are discussed. |
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Authors:
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N Mechti; J P Leonetti; J P Clarenc; G Degols; B Lebleu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleic acids symposium series Volume: - ISSN: 0261-3166 ISO Abbreviation: Nucleic Acids Symp. Ser. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-11-25 Completed Date: 1992-11-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007206 Medline TA: Nucleic Acids Symp Ser Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 147-50 Citation Subset: IM |
Affiliation:
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Laboratoire de Biochimie des Proteines, UA CNRS 1191, Université de Montpellier II, Montpellier, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / metabolism* Culture Media, Serum-Free Fibroblasts / metabolism Microinjections Oligonucleotides / chemical synthesis, metabolism* Oligonucleotides, Antisense / chemical synthesis, metabolism* RNA, Messenger / genetics RNA, Small Nuclear / metabolism Ribonucleoproteins, Small Nuclear / metabolism Vesicular stomatitis Indiana virus / genetics |
| Chemical | |
Reg. No./Substance:
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0/Culture Media, Serum-Free; 0/Oligonucleotides; 0/Oligonucleotides, Antisense; 0/RNA, Messenger; 0/RNA, Small Nuclear; 0/Ribonucleoproteins, Small Nuclear |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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