Document Detail

Nuclear expression of thioredoxin-1 in the invasion front is associated with outcome in patients with gallbladder carcinoma.
MedLine Citation:
PMID:  22882193     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Multifunctional redox protein human thioredoxin (TRX-1) is reduced by thioredoxin reductase (TRX-R). The aim of the present study was to examine the distribution of TRX-1 and TRX-R expressions in gallbladder carcinoma (GBC) to clarify their usefulness as prognostic factors after surgical resection.
METHODS: Immunohistochemical staining for TRX-1 and TRX-R was performed in GBC tissue from 38 patients who underwent surgical resection, and TRX-1/TRX-R localization in relation to outcome was examined.
RESULTS: TRX-1 protein levels were significantly higher in GBC samples than in cholecystolithiasis samples (P = 0.0174). TRX-1 expression was observed in 100% (38/38) of tumour samples and in the nucleus in 76% (29/38), with nuclear expression in the invasion front observed in 45% (13/29). TRX-R expression was only detected in the cytoplasm of cancer cells and in the invasion front in 28 samples. In all of the samples, the depth of tumour invasion, lymph node metastasis, surgical margin, curability and nuclear expression of TRX-1 in the invasion front were significant prognostic factors by univariate analysis. In 27 selected patients who underwent curative resection, both TRX-1 nuclear expression and TRX-R cytoplasmic expression in the invasion front was a significantly prognostic factor.
CONCLUSION: TRX-1 nuclear expression in the GBC invasion front is a significant prognostic marker. Patients with both TRX-1 nuclear expression and TRX-R cytoplasmic expression in the tumour invasion front should be observed carefully even if after curative resection.
Motoaki Nagano; Kinta Hatakeyama; Masahiro Kai; Hajime Nakamura; Junji Yodoi; Yujiro Asada; Kazuo Chijiiwa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-08
Journal Detail:
Title:  HPB : the official journal of the International Hepato Pancreato Biliary Association     Volume:  14     ISSN:  1477-2574     ISO Abbreviation:  HPB (Oxford)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2012-12-26     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  100900921     Medline TA:  HPB (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-82     Citation Subset:  IM    
Copyright Information:
© 2012 International Hepato-Pancreato-Biliary Association.
Department of Surgical Oncology and Regulation of Organ Function, Miyazaki University School of Medicine, Kiyotake, Miyazaki, Japan.
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MeSH Terms
Aged, 80 and over
Blotting, Western
Carcinoma / chemistry*,  mortality,  secondary,  surgery
Cell Nucleus / chemistry*
Cytoplasm / chemistry
Gallbladder Neoplasms / chemistry*,  mortality,  pathology,  surgery
Kaplan-Meier Estimate
Lymphatic Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Thioredoxin-Disulfide Reductase / analysis
Thioredoxins / analysis*
Treatment Outcome
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/TXN protein, human; 0/Tumor Markers, Biological; 52500-60-4/Thioredoxins; EC Reductase
Comment In:
HPB (Oxford). 2012 Sep;14(9):571-2   [PMID:  22882192 ]

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