| Nuclear expression of GSK-3β and lack of membranous β-catenin is correlated with poor survival in colon cancer. | |
| | |
MedLine Citation:
|
PMID: 23389968 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dysregulation of Wnt/β-catenin signaling is a hallmark of colon cancer. Glycogen synthase kinase-3β (GSK-3β) can be a positive regulator of survival and proliferation of cultured colon cancer cell but its role in clinical colon cancer is unknown. Our objectives were to evaluate the role of GSK-3β in colon cancer. A tumor tissue microarray of primary colon cancers and metastases was used to evaluate expression and subcellular localization of GSK-3β and β-catenin. 85 primary colon cancer samples were evaluated by immunohistochemistry. Immunoreactivity was correlated to known markers of adverse prognosis. Overall survival was the primary end-point. We found nuclear accumulation of GSK-3β in 39% (33 out of 85) of evaluated tumors. Nuclear GSK-3β was significantly associated with shorter overall survival (p=0.008), larger tumor size (p=0.015), distant metastasis (p=0.029) and loss of membranous β-catenin (p=0.007). Loss of membranous β-catenin occurred in 37% (30/82) of the tumors and was associated with poor survival (p=0.016). The combination of nuclear GSK-3β and lack of membrane β-catenin occurred in a total of 26% of the studied tumors (21/61) and was significantly and independently associated with poor prognosis. Our results suggest that nuclear expression of GSK-3β and loss of membrane β-catenin identify a subset of colon carcinomas with worse prognosis. © 2013 Wiley Periodicals, Inc. |
| | |
Authors:
|
Tavga Salim; Anita Sjölander; Janna Sand-Dejmek |
Related Documents
:
|
12709738 - Psychometric testing of the translated mcgill quality of life questionnaire-taiwan vers... 19731348 - Quality of life in a prospective cohort of elderly women with and without cancer. 18339668 - Psychometric evaluation of the european organization for research and treatment of canc... 23649548 - Cullin 4b is a novel prognostic marker that correlates with colon cancer progression an... 17012048 - Clinical role of proton magnetic resonance spectroscopy in oncology: brain, breast, and... 17987458 - Breast cancer prevention with older women: a gender-focused intervention study. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-7 |
Journal Detail:
|
Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2009 UICC. |
Affiliation:
|
CellandExperimental Pathology, Department of Laboratory Medicine, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heat-treated emulsions with cross-linking bovine serum albumin interfacial films and different dextr...
Next Document: Simultaneous magnetic resonance angiography and perfusion (MRAP) measurement: Initial application in...