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Nuclear expression of GSK-3β and lack of membranous β-catenin is correlated with poor survival in colon cancer.
MedLine Citation:
PMID:  23389968     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dysregulation of Wnt/β-catenin signaling is a hallmark of colon cancer. Glycogen synthase kinase-3β (GSK-3β) can be a positive regulator of survival and proliferation of cultured colon cancer cell but its role in clinical colon cancer is unknown. Our objectives were to evaluate the role of GSK-3β in colon cancer. A tumor tissue microarray of primary colon cancers and metastases was used to evaluate expression and subcellular localization of GSK-3β and β-catenin. 85 primary colon cancer samples were evaluated by immunohistochemistry. Immunoreactivity was correlated to known markers of adverse prognosis. Overall survival was the primary end-point. We found nuclear accumulation of GSK-3β in 39% (33 out of 85) of evaluated tumors. Nuclear GSK-3β was significantly associated with shorter overall survival (p=0.008), larger tumor size (p=0.015), distant metastasis (p=0.029) and loss of membranous β-catenin (p=0.007). Loss of membranous β-catenin occurred in 37% (30/82) of the tumors and was associated with poor survival (p=0.016). The combination of nuclear GSK-3β and lack of membrane β-catenin occurred in a total of 26% of the studied tumors (21/61) and was significantly and independently associated with poor prognosis. Our results suggest that nuclear expression of GSK-3β and loss of membrane β-catenin identify a subset of colon carcinomas with worse prognosis. © 2013 Wiley Periodicals, Inc.
Authors:
Tavga Salim; Anita Sjölander; Janna Sand-Dejmek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2009 UICC.
Affiliation:
CellandExperimental Pathology, Department of Laboratory Medicine, Sweden.
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