| Nuclear bile acid receptor FXR in the hepatic regeneration. | |
| | |
MedLine Citation:
|
PMID: 21167938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The liver can fully regenerate itself by a compensatory regrowth in response to partial hepatectomy or injury. This process consists of a variety of well-orchestrated phases and is mediated by many signals. Farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Bile acids are FXR physiological ligands. As a metabolic regulator, FXR plays key roles in regulating metabolism of bile acids, lipids and glucose. Recently, bile acid/FXR signaling pathway is shown to be required for normal liver regeneration. Furthermore, FXR promotes liver repair after injury and activation of FXR is able to alleviate age-related defective liver regeneration. These novel findings suggest that FXR-mediated bile acid signaling is an integrated component of normal liver regeneration machinery, and also highlight the potential use of FXR ligands to promote liver regeneration after segmental liver transplantation or resection of liver tumors. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. |
| | |
Authors:
|
Wei-Dong Chen; Yan-Dong Wang; Zhipeng Meng; Lisheng Zhang; Wendong Huang |
Related Documents
:
|
9989278 - Binding of fatty acid ethyl esters to albumin for transport to cells in culture. 5782358 - Influence of ph of the medium on free fatty acid utilization by isolated mammalian cells. 4064218 - Spectroscopic investigations on the binding site of bovine hepatic fatty acid binding p... 8566218 - Neutrophils convert tyrosyl residues in albumin to chlorotyrosine. 23171868 - The effects of palmitic acid on nitric oxide production by rat skeletal muscle: mechani... 15657038 - Folding competence of n-terminally truncated forms of human procathepsin b. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-15 |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: - ISSN: 0006-3002 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2011-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Embryonic ethanol exposure alters synaptic properties at zebrafish neuromuscular junctions.
Next Document: The role of the organ microenvironment in brain metastasis.