Document Detail

Nuclear actin: an apparent association with condensed chromatin.
MedLine Citation:
PMID:  610879     Owner:  NLM     Status:  MEDLINE    
In Amoeba proteus the concentration of actin is the same in the nucleus and cytoplasm. Certain characteristics, e.g., the ready loss of actin from isolated nuclei, suggest that the association with nuclei is normally not a tight one. Here we report, however, that when nuclei are isolated several hours after mitotic amebas are placed in actinomycin D (which allows normal progression of mitosis), the nuclei retain substantial amounts of actin. Since this finding correlates with other observations that the chromatin of such cells is extensively condensed, we suggest that a relationship may exist between actin and chromatin condensation.
L Goldstein; C Ko; J Errick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell biology international reports     Volume:  1     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-5     Citation Subset:  IM    
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MeSH Terms
Actins / metabolism*
Amoeba / ultrastructure*
Cell Nucleus / metabolism
Chromatin / metabolism*
Dactinomycin / pharmacology
Reg. No./Substance:
0/Actins; 0/Chromatin; 50-76-0/Dactinomycin

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