Document Detail

Nuclear PI(4,5)P(2): a new place for an old signal.
MedLine Citation:
PMID:  16750654     Owner:  NLM     Status:  MEDLINE    
Over the last decades, evidence has accumulated suggesting that there is a distinct nuclear phosphatidylinositol pathway. One of the best examined nuclear lipid pathways is the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) by PLC resulting in activation of nuclear PKC and production of inositol polyphosphates. However, there is a growing number of data that phosphoinositides are not only precursor for soluble inositol phosphates and diacylglycerol, instead they can act as second messengers themselves. They have been implicated to play a role in different important nuclear signaling events such as cell cycle progression, apoptosis, chromatin remodeling, transcriptional regulation and mRNA processing. This review focuses on the role of specifically PI4,5P(2) in the nucleus as a second messenger as well as a precursor for PI3,4,5P3, inositol polyphosphates and diacylglycerol.
Matthew W Bunce; Karen Bergendahl; Richard A Anderson
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-03-29
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1761     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  560-9     Citation Subset:  IM    
Department of Pharmacology, University of Wisconsin Medical School, 1300 University Ave., Madison, WI 53706, USA.
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MeSH Terms
Cell Nucleus / metabolism*
Cell Physiological Phenomena*
Nuclear Envelope / metabolism*
Phosphatidylinositol 4,5-Diphosphate / metabolism*
Signal Transduction / physiology*
Type C Phospholipases / metabolism*
Reg. No./Substance:
0/Phosphatidylinositol 4,5-Diphosphate; EC 3.1.4.-/Type C Phospholipases

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