Document Detail

Nuclear matrix association: switching to the invasive cytotrophoblast.
MedLine Citation:
PMID:  20346505     Owner:  NLM     Status:  MEDLINE    
Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human cytotrophoblast cell line which displays well characterized invasive and non-invasive behavior, and to correlate the activity of the transcriptome with nuclear matrix attachment and cell phenotype. Comparison of the invasive to non-invasive HTR transcriptomes was unremarkable. In contrast, comparison of the MARs on chromosomes 14-18 revealed an increased number of MARs associated with the invasive phenotype. These attachment areas were more likely to be associated with silent rather than actively transcribed genes. This study supports the view that nuclear matrix attachment may play an important role in cytotrophoblast invasion by ensuring specific silencing that facilitates invasion.
K J Drennan; A K Linnemann; A E Platts; H H Heng; D R Armant; S A Krawetz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-03-25
Journal Detail:
Title:  Placenta     Volume:  31     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-08-03     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Ltd. All rights reserved.
Department of Obstetrics and Gynecology, Wayne State University, 253 C. S. Mott Center, 275 E. Hancock St., Detroit, MI 48201, USA.
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MeSH Terms
Blotting, Western
Cell Differentiation
Cells, Cultured
Comparative Genomic Hybridization
Gene Silencing
Matrix Attachment Regions / genetics*
Nuclear Matrix / genetics*,  metabolism
Pregnancy Trimester, First
Spectral Karyotyping
Trophoblasts / cytology*,  metabolism
Grant Support

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