| Nuclear DNA measurements in follicular thyroid adenomas. | |
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MedLine Citation:
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PMID: 2703057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nuclear DNA content was measured retrospectively in histologically confirmed follicular adenomas in 20 patients, and prospectively in 25 patients. In the retrospective group two of the adenomas, and in the prospective group three of the adenomas were classified as atypical due to high cellularity and nuclear atypia, but with no sign of micro-invasive growth. In the group of patients studied retrospectively, the two patients with atypical adenoma had an aneuploid DNA pattern. One of these died 11 years after diagnosis with generalized disease. The other patient in this group with an aneuploid atypical adenoma is alive, as are all the remaining 18 patients with diploid adenomas. In the prospective group there were five aneuploid tumours. The atypical adenomas were aneuploid in two cases and polyploid in one case. No patient in the prospective group has shown any evidence of recurrence so far. Although DNA measurements are of value in distinguishing between low and high malignant potential in invasive tumors, the prognostic information if no invasion is found is uncertain. The importance of examining an adequate number of tissue blocks from the capsular region is emphasized. |
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Authors:
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M Bäckdahl; G Wallin; U Askensten; G Auer; L Grimelius; T Löwhagen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Volume: 15 ISSN: 0748-7983 ISO Abbreviation: Eur J Surg Oncol Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-05-18 Completed Date: 1989-05-18 Revised Date: 2007-07-02 |
Medline Journal Info:
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Nlm Unique ID: 8504356 Medline TA: Eur J Surg Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Karolinska Institute, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
genetics*,
secondary,
surgery Adolescent Adult Aneuploidy Cell Nucleus / analysis DNA, Neoplasm / analysis* Diploidy Female Humans Male Middle Aged Prognosis Prospective Studies Retrospective Studies Spinal Neoplasms / secondary Thyroid Neoplasms / genetics*, surgery |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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