Document Detail


Nuclear DNA measurements in follicular thyroid adenomas.
MedLine Citation:
PMID:  2703057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nuclear DNA content was measured retrospectively in histologically confirmed follicular adenomas in 20 patients, and prospectively in 25 patients. In the retrospective group two of the adenomas, and in the prospective group three of the adenomas were classified as atypical due to high cellularity and nuclear atypia, but with no sign of micro-invasive growth. In the group of patients studied retrospectively, the two patients with atypical adenoma had an aneuploid DNA pattern. One of these died 11 years after diagnosis with generalized disease. The other patient in this group with an aneuploid atypical adenoma is alive, as are all the remaining 18 patients with diploid adenomas. In the prospective group there were five aneuploid tumours. The atypical adenomas were aneuploid in two cases and polyploid in one case. No patient in the prospective group has shown any evidence of recurrence so far. Although DNA measurements are of value in distinguishing between low and high malignant potential in invasive tumors, the prognostic information if no invasion is found is uncertain. The importance of examining an adequate number of tissue blocks from the capsular region is emphasized.
Authors:
M Bäckdahl; G Wallin; U Askensten; G Auer; L Grimelius; T Löwhagen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  15     ISSN:  0748-7983     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Department of Surgery, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / genetics*,  secondary,  surgery
Adolescent
Adult
Aneuploidy
Cell Nucleus / analysis
DNA, Neoplasm / analysis*
Diploidy
Female
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Retrospective Studies
Spinal Neoplasms / secondary
Thyroid Neoplasms / genetics*,  surgery
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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