Document Detail


Nuchal translucency in multiple pregnancies.
MedLine Citation:
PMID:  10962045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To evaluate the prevalence of increased nuchal translucency (NT) in multiple pregnancies and its relation to fetal karyotype and pregnancy outcome. METHODS: We measured fetal nuchal translucency (NT) in 6,338 women pregnant from 10+3 to 13+6 weeks by ultrasound and evaluated the prevalence of NT=95th centile in 115 multiple pregnancies, including 100 pairs of twins (70 dichorionic and 30 monochorionic placentas), 9 triplets, 5 quadruplets, and one quintuplet. Chorionicity, fetal karyotype, and pregnancy outcome were also evaluated in 400 singleton pregnancies. RESULTS: NT=95th centile in a single fetus was found in 10/70 cases of dichorionic twin pregnancies (14%), in two quadruplets, in 7/30 monochorionic twin pregnancies (23.3%), and in both fetuses in one dichorionic twin pregnancy. In the control group, NT=95th centile was found in 17/400 (4.2%) cases. In multiple pregnancies, two cases of trisomy 21 and one of 47, XXY were found. NT=95th centile was found in 2/2 fetuses with trisomy 21 (one dichorionic twin pregnancy and one tetrachorionic pregnancy), but not in the 47, XXY trisomy (trichorionic triplet pregnancy). A skeletal dysplasia and a Goldenhar syndrome were found among the 10 dichorionic pregnancies with increased NT. Three intrauterine deaths of both fetuses, one congenital heart disease, and a case of twin-to-twin transfusion occurred in 7 monochorionic pregnancies with increased NT. CONCLUSION: Increased NT in multiple pregnancies indicates fetuses at risk of chromosomal abnormalities and fetal malformation, and monochorionic twin pregnancies at higher risk of adverse outcome.
Authors:
G Monni; M A Zoppi; R M Ibba; M Putzolu; M Floris
Related Documents :
18726925 - Screening for trisomy 18 by maternal age, fetal nuchal translucency, free beta-human ch...
2524035 - The dilemma of chromosomal mosaicism in chorionic villus sampling--'direct' versus long...
1919285 - Nuchal cord: a definition and a study associating placental location and nuchal cord in...
10227405 - Trisomy/tetrasomy 21 mosaicism in cvs: interpretation of cytogenetic discrepancies betw...
25190675 - An early pregnancy hba1c ≥5.9% (41 mmol/mol) is optimal for detecting diabetes and iden...
10426615 - Twin mothers, pregnancy hypertension and pre-eclampsia.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Croatian medical journal     Volume:  41     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  266-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Prenatal and Preimplantation Genetic Diagnosis, Fetal Therapy, Ospedale Regionale per le Microcitemie, Via Jenner 09121 Cagliari, Italy. prenatalmonni@tiscalinet.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chromosome Aberrations / ultrasonography
Chromosome Disorders
Congenital Abnormalities / ultrasonography*
Female
Humans
Neck / ultrasonography*
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple*
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Three-dimensional ultrasound for routine check-up in in vitro fertilization patients.
Next Document:  Substance abuse in the Republic of Croatia and National Program for Drug Control.