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Nuchal translucency and cardiac abnormalities in euploid singleton pregnancies.
MedLine Citation:
PMID:  23806115     Owner:  NLM     Status:  Publisher    
Abstract Objective: To investigate different cut-off levels of nuchal translucency (NT) to predict abnormal cardiac findings (ACF) in second trimester ultrasound examination and confirmed postnatal congenital heart defects (CHD) in euploid pregnancies. Methods: A retrospective analysis was performed on singleton pregnancies examined in our ultrasound units from 2006 to 2011. Fetuses with an abnormal karyotype were excluded. Different cut-off levels of NT thickness were analyzed to evaluate its performance to detect the ACF on second trimester ultrasound examination (2(nd) US) and also the CHD detected in neonatal follow-up evaluation of ACF cases. Results: Of 12,840 cases, a total number of 8541 euploid pregnancies were included in the study. Thirty-three had ACFs detected by 2(nd) US (3.86/1000). The mean NT thickness was found to be higher in fetuses with ACFs (P < 0.0001). Of 33 ACFs, 17 (52%, 1.99/1000) had major CHDs in neonatal follow-up. The area under the ROC curves for NT thickness to predict ACFs and CHDs were 0.67 and 0.65, respectively. Conclusions: Higher NT thickness are associated with higher risk of ACF. NT is a weak predictor of ACF and major CHD; however, fetuses with an unexplained increase in NT measurement should be referred for further cardiac investigations.
Alireza A Shamshirsaz; Bahram Salmanian; Samadh F Ravangard; Amirhoushang A Shamshirsaz; Pouya Javadian; Adam Borgida; Garry Turner; Deborah Feldman; Melissa Spiel; Peter Benn; Winston A Campbell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, CT.
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