Document Detail


The NuRD architecture.
MedLine Citation:
PMID:  23340908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and discuss new avenues of research to advance our understanding of the NuRD-mediated signaling network.
Authors:
Hillary F Allen; Paul A Wade; Tatiana G Kutateladze
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Review     Date:  2013-01-23
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  70     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-12     Completed Date:  2014-02-20     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3513-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics*,  metabolism*
Signal Transduction
Grant Support
ID/Acronym/Agency:
GM096863/GM/NIGMS NIH HHS; R01 GM096863/GM/NIGMS NIH HHS; T32HD041697/HD/NICHD NIH HHS; Z01ES101965/ES/NIEHS NIH HHS; ZIA ES101965-08/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
EC 3.5.1.98/Mi-2 Nucleosome Remodeling and Deacetylase Complex
Comments/Corrections

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