Document Detail


Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.
MedLine Citation:
PMID:  9872330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated induction of detoxifying enzymes in response to antioxidants and xenobiotics. Nrf-Jun association/heterodimerization and binding to the ARE required unknown cytosolic factor(s). Nrf2 containing one mutated leucine in its leucine zipper region was more efficient in upregulation of ARE-mediated gene expression, as compared to Nrf1 with two mutated leucines.
Authors:
R Venugopal; A K Jaiswal
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Oncogene     Volume:  17     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-26     Completed Date:  1999-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3145-56     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Baylor College of Medicine, Texas 77030-3498, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antioxidants / pharmacology
Binding Sites
Collagenases / genetics*
DNA-Binding Proteins / genetics,  metabolism*
Gene Expression Regulation*
Glutathione Transferase / genetics*
Humans
Leucine Zippers* / genetics
Molecular Sequence Data
NAD(P)H Dehydrogenase (Quinone) / genetics*
NF-E2-Related Factor 1
NF-E2-Related Factor 2
Nuclear Respiratory Factor 1
Nuclear Respiratory Factors
Proto-Oncogene Proteins c-fos / genetics,  metabolism
Proto-Oncogene Proteins c-jun / genetics,  metabolism*
Rats
Sequence Homology, Amino Acid
Trans-Activators / genetics,  metabolism*
Tumor Cells, Cultured
beta-Naphthoflavone / pharmacology
Grant Support
ID/Acronym/Agency:
GM47466/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/DNA-Binding Proteins; 0/NF-E2-Related Factor 1; 0/NF-E2-Related Factor 2; 0/NFE2L2 protein, human; 0/NRF1 protein, human; 0/Nfe2l1 protein, rat; 0/Nfe2l2 protein, rat; 0/Nuclear Respiratory Factor 1; 0/Nuclear Respiratory Factors; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Trans-Activators; 6051-87-2/beta-Naphthoflavone; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 2.5.1.18/Glutathione Transferase; EC 3.4.24.-/Collagenases

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