Document Detail


Noxious stimulation during orthopaedic surgery results in EEG 'arousal' or 'paradoxical arousal' reaction in isoflurane-anaesthetised sheep.
MedLine Citation:
PMID:  12893158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of surgical stimuli on haemodynamic and electroencephalographic (EEG) variables were determined in 25 adult ewes undergoing an experimental orthopaedic procedure in isoflurane anaesthesia. Data were recorded after 15 min of constant end-tidal concentration of approximately 2.2% isoflurane (SS: steady state=baseline), during skin disinfection (DIS), incision (INC), drilling of the first hole through the tibia (DRI) and insertion of a threaded pin (PIN) for external fixation. Stimulation resulted in a significant increase in systolic and mean arterial pressure above SS at INC, DRI and PIN. Haemodynamic changes were accompanied by either significant increases or decreases in EEG median frequency (MF) and 80% spectral edge frequency (SEF80) above or below SS at all four stimulation time points suggesting 'arousal' or 'paradoxical arousal' reaction, respectively. We conclude, that either type of EEG activation pattern could be elicited dependent on stimulation intensity and level of anaesthetic depth.
Authors:
Klaus A Otto; Petra Mally
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  75     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  IM    
Affiliation:
Hannover Medical School, Laboratory Animal Facility, Carl-Neuberg-Str 1, D-30625, Hannover, Germany. otto.klaus@mh-hannover.de
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General / veterinary*
Anesthetics, Inhalation / administration & dosage*
Animals
Arousal / drug effects*
Electroencephalography / veterinary*
Female
Hemodynamics / drug effects
Intraoperative Period
Isoflurane / administration & dosage*
Monitoring, Intraoperative / veterinary
Orthopedic Procedures / veterinary*
Sheep*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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