Document Detail

Noxious stimulation during orthopaedic surgery results in EEG 'arousal' or 'paradoxical arousal' reaction in isoflurane-anaesthetised sheep.
MedLine Citation:
PMID:  12893158     Owner:  NLM     Status:  MEDLINE    
The effects of surgical stimuli on haemodynamic and electroencephalographic (EEG) variables were determined in 25 adult ewes undergoing an experimental orthopaedic procedure in isoflurane anaesthesia. Data were recorded after 15 min of constant end-tidal concentration of approximately 2.2% isoflurane (SS: steady state=baseline), during skin disinfection (DIS), incision (INC), drilling of the first hole through the tibia (DRI) and insertion of a threaded pin (PIN) for external fixation. Stimulation resulted in a significant increase in systolic and mean arterial pressure above SS at INC, DRI and PIN. Haemodynamic changes were accompanied by either significant increases or decreases in EEG median frequency (MF) and 80% spectral edge frequency (SEF80) above or below SS at all four stimulation time points suggesting 'arousal' or 'paradoxical arousal' reaction, respectively. We conclude, that either type of EEG activation pattern could be elicited dependent on stimulation intensity and level of anaesthetic depth.
Klaus A Otto; Petra Mally
Related Documents :
3083728 - Isoflurane, halothane, and regional cerebral blood flow at various levels of paco2 in r...
19795938 - Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetiz...
7839598 - Determination of the ed50 of isoflurane and evaluation of the isoflurane-sparing effect...
7948408 - Sevoflurane anesthesia following administration of atropine-guaifenesin-thiopental in s...
18240698 - Community-based weight management in long-term heart transplant recipients: a pilot study.
18576468 - Low-pressure airlift fermenter for single cell protein production: ii. continuous cultu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  75     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  IM    
Hannover Medical School, Laboratory Animal Facility, Carl-Neuberg-Str 1, D-30625, Hannover, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, General / veterinary*
Anesthetics, Inhalation / administration & dosage*
Arousal / drug effects*
Electroencephalography / veterinary*
Hemodynamics / drug effects
Intraoperative Period
Isoflurane / administration & dosage*
Monitoring, Intraoperative / veterinary
Orthopedic Procedures / veterinary*
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bone marrow edema syndrome of the knee: a case report and review of the literature.
Next Document:  Biochemical characterisation of navicular hyaline cartilage, navicular fibrocartilage and the deep d...