| Noxious stimulation during orthopaedic surgery results in EEG 'arousal' or 'paradoxical arousal' reaction in isoflurane-anaesthetised sheep. | |
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MedLine Citation:
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PMID: 12893158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of surgical stimuli on haemodynamic and electroencephalographic (EEG) variables were determined in 25 adult ewes undergoing an experimental orthopaedic procedure in isoflurane anaesthesia. Data were recorded after 15 min of constant end-tidal concentration of approximately 2.2% isoflurane (SS: steady state=baseline), during skin disinfection (DIS), incision (INC), drilling of the first hole through the tibia (DRI) and insertion of a threaded pin (PIN) for external fixation. Stimulation resulted in a significant increase in systolic and mean arterial pressure above SS at INC, DRI and PIN. Haemodynamic changes were accompanied by either significant increases or decreases in EEG median frequency (MF) and 80% spectral edge frequency (SEF80) above or below SS at all four stimulation time points suggesting 'arousal' or 'paradoxical arousal' reaction, respectively. We conclude, that either type of EEG activation pattern could be elicited dependent on stimulation intensity and level of anaesthetic depth. |
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Authors:
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Klaus A Otto; Petra Mally |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research in veterinary science Volume: 75 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2003-09-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 103-12 Citation Subset: IM |
Affiliation:
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Hannover Medical School, Laboratory Animal Facility, Carl-Neuberg-Str 1, D-30625, Hannover, Germany. otto.klaus@mh-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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veterinary* Anesthetics, Inhalation / administration & dosage* Animals Arousal / drug effects* Electroencephalography / veterinary* Female Hemodynamics / drug effects Intraoperative Period Isoflurane / administration & dosage* Monitoring, Intraoperative / veterinary Orthopedic Procedures / veterinary* Sheep* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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