| Nox-generated ROS modulate glucose uptake in a leukaemic cell line. | |
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MedLine Citation:
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PMID: 18473264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of superoxide-generating enzymes homologues of phagocytic NAD(P)H oxidase, the Nox family, has led to the concept that reactive oxygen species (ROS) are 'intentionally' generated with biological functions in various cell types. In this study, by treating an acute leukaemic cell line with different antioxidants, ROS generation was shown to be crucially involved in the modulation of glucose transport (mediated by Glut1), which is frequently up-regulated in cancer cells. Then, this study tried to elucidate ROS source(s) and mechanisms by which ROS are involved in Glut1 activity regulation. Results prove that Nox2 and Nox4 are the candidates and that phosphorylation processes are important in the regulation of glucose uptake on which cancer cells rely. On the whole, data suggest that both Glut1 and Nox homologues may be considered new potential targets in the treatment of leukaemia. |
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Authors:
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Cecilia Prata; Tullia Maraldi; Diana Fiorentini; Laura Zambonin; Gabriele Hakim; Laura Landi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 42 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-08-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 405-14 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Bologna, Italy. cecilia.prata@unibo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism Biological Transport Cell Line, Tumor Gene Expression Regulation, Enzymologic* Gene Expression Regulation, Leukemic* Glucose / metabolism, pharmacokinetics* Glucose Transporter Type 1 / metabolism Humans Leukemia / therapy* Membrane Glycoproteins / metabolism* NADPH Oxidase / metabolism* Phosphorylation Protein Isoforms Protein-Tyrosine Kinases / metabolism Reactive Oxygen Species* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/CYBB protein, human; 0/Glucose Transporter Type 1; 0/Membrane Glycoproteins; 0/Protein Isoforms; 0/Reactive Oxygen Species; 0/SLC2A1 protein, human; 50-99-7/Glucose; EC 1.6.3.-/NOX4 protein, human; EC 1.6.3.1/NADPH Oxidase; EC 2.7.10.1/Protein-Tyrosine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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