Document Detail


Novelty detection and encoding for declarative memory within the human hippocampus.
MedLine Citation:
PMID:  17073169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracranial recordings of cognitive potentials within the human hippocampal system have identified N400 potentials in the anterior mesial temporal lobe (AMTL-N400) that correlate with verbal memory performance and are associated with novelty detection. Their amplitudes to "new" but not "old" words in a verbal recognition task correlate with the neuronal density of the hippocampal CA1-region and can be reduced selectively by the NMDA-receptor blocker ketamine. Moreover, it could be shown that NMDA-receptor dependent long-term potentiation (LTP), a form of synaptic plasticity with Hebbian characteristics, can be readily induced in human hippocampal slices but not in patients with hippocampal sclerosis. In these latter patients, we also found a reduction of AMTL-N400 amplitudes similar to the one induced by ketamine. In addition, we could show that hippocampal novelty detection is associated with successful encoding for declarative memory. Together, our findings suggest that successful encoding for declarative memory is at least in part mediated by NMDA-receptor dependent novelty detection within the human hippocampal system.
Authors:
Thomas Grunwald; Martin Kurthen
Related Documents :
19385719 - From rapid place learning to behavioral performance: a key role for the intermediate hi...
24518429 - Potential benefits and limitations of three types of directional processing in hearing ...
18609419 - Hippocampal remodelling after mdma neurotoxicity: a single case study.
2770879 - Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic reso...
17981399 - Functional implications of decreases in neurogenesis following chronic mild stress in m...
17393499 - Modulation of normal and altered hippocampal excitability states by septal networks.
17963999 - Hippocampal volume is an independent predictor of cognitive performance in cadasil.
21697249 - Hippocampal size and memory functioning in children and adolescents with congenital hyp...
24925239 - Differential involvement of right and left hemisphere in individual recognition in the ...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical EEG and neuroscience     Volume:  37     ISSN:  1550-0594     ISO Abbreviation:  Clin EEG Neurosci     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2006-12-07     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101213033     Medline TA:  Clin EEG Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Electroencephalography
Epilepsy, Temporal Lobe / physiopathology
Evoked Potentials, Auditory / physiology
Hippocampus / physiology*
Humans
Memory / physiology*
Speech Perception / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electromagnetic correlates of recognition memory processes.
Next Document:  Electrophysiological measures of episodic memory control and memory retrieval.