| Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure. | |
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MedLine Citation:
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PMID: 12018885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role for beta blockers in advanced heart failure (New York Heart Association class IV) remains undefined because of concerns about tolerability and uncertainty about efficacy. We report the use of a short-acting intravenous beta blocker in combination with inotropic therapy as a means to bridge five patients with advanced heart failure to chronic oral beta blockade; two of these patients had been chronically managed with intravenous inotrope. At 4 months' follow-up, all patients remained on beta-blocker therapy and none was hospitalized for heart failure or had received intravenous diuretics. Given the early separation of survival curves in the randomized clinical trials of beta blockers in heart failure, it is possible that these patients will accrue a survival benefit. We conclude that some patients with advanced heart failure can be offered oral beta-blocker therapy by bridging with a combination of intravenous inotrope and short-acting intravenous beta blocker. |
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Authors:
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Paul J Hauptman; Daniel Woods; Marc R Prirzker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 25 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-20 Completed Date: 2002-12-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 247-9 Citation Subset: IM |
Affiliation:
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Saint Louis University School of Medicine, St Louis, Missouri, USA. Hauptmpj@slu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
therapeutic use* Carbazoles / administration & dosage, therapeutic use* Cardiotonic Agents / administration & dosage, therapeutic use* Drug Therapy, Combination Heart Failure / drug therapy* Humans Infusions, Intravenous Metoprolol / administration & dosage, therapeutic use* Milrinone / administration & dosage, therapeutic use* Propanolamines / administration & dosage, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Cardiotonic Agents; 0/Propanolamines; 37350-58-6/Metoprolol; 72956-09-3/carvedilol; 78415-72-2/Milrinone; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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