Document Detail

Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus.
MedLine Citation:
PMID:  22162264     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We studied the acute safety and feasibility of a pericardium-covered stent (PCS) in the obliteration of massive coronary thrombus.
BACKGROUND: Thrombus is frequently encountered in the setting of acute myocardial infarction, and conventional pharmacological and aspiration approaches are not always successful in dispersing or removing it, especially when it is very substantial.
METHODS: We treated nine patients (10 lesions) in the setting of an acute coronary syndrome characterized by the presence of substantial (TIMI grade 3-4) thrombus in a large caliber native coronary artery, persisting after conventional treatment, with percutaneous implantation of an equine PCS graft. Nine of 10 lesions were in large right coronary arteries.
RESULTS: Deployment was successful in nine of 10 lesions. In all nine cases, the filling defect was immediately eliminated and there was restoration or maintenance of TIMI grade 3 blood flow. There was one in-hospital stent thrombosis in a 56-year-old male, who had only received aspirin due to a coexistent stroke. This patient underwent successful repeat percutaneous intervention but died later of complications of the stroke. There were no 30-day events, and medium-term follow-up continues.
CONCLUSIONS: A PCS graft is a potentially useful device to treat massive thrombus burden in the setting of acute coronary syndrome. A larger study is warranted.
Julian Gunn; Anjan Siotia; Christopher J Malkin; Javaid Iqbal; Tushar Raina; Allison C Morton
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-12-08
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  80     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-27     Completed Date:  2012-10-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Acute Coronary Syndrome / etiology,  mortality,  therapy*
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*,  mortality
Blood Vessel Prosthesis*
Blood Vessel Prosthesis Implantation / adverse effects,  instrumentation*,  mortality
Coronary Angiography
Coronary Thrombosis / complications,  mortality,  radiography,  therapy*
Feasibility Studies
Middle Aged
Pericardium / transplantation*
Transplantation, Heterologous
Treatment Outcome
Comment In:
Catheter Cardiovasc Interv. 2012 Jul 1;80(1):65-6   [PMID:  22736587 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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