Document Detail


Novel trends in celiac disease.
MedLine Citation:
PMID:  21278765     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Celiac disease (CD) is one of the most common food intolerances in developed world. It affects genetically susceptible individuals and has severe consequences if it remains undiagnosed. A disease known for more than a century, it is still the focus for experts from various fields of research and development. Geneticists, pathologists, immunologists, food engineers and dieticians share their knowledge and expertise to improve the conditions of CD patients. With new insights in the pathomechanism of gluten processing and antigen presentation in CD, it was possible to improve the diagnostic antigen mimicking the primary epitope in CD. These celiac neo-epitopes are comprised of a complex of gliadin peptides crosslinked with transglutaminase (tTg). They are an early diagnostic marker for CD which occurs up to 6 months earlier than classical markers known to miss a certain amount of CD patients.Cellular & Molecular Immunology advance online publication, 31 January 2011; doi:10.1038/cmi.2010.68.
Authors:
Torsten Matthias; Sandra Neidhöfer; Sascha Pfeiffer; Kai Prager; Sandra Reuter; M Eric Gershwin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-31
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  -     ISSN:  2042-0226     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
AESKU.KIPP Institute, Wendelsheim, Germany.
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