Document Detail


Novel therapy for myocardial infarction: can HGF/Met be beneficial?
MedLine Citation:
PMID:  21327916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial infarction (MI) is a leading cause of hospitalization worldwide. A recently developed strategy to improve the management of MI is based on the use of growth factors which are able to enhance the intrinsic capacity of the heart to repair itself or regenerate after damage. Among others, hepatocyte growth factor (HGF) has been proposed as a modulator of cardiac repair of damage due to the pleiotropic effects elicited by Met receptor stimulation. In this review we describe the mechanistic basis for autocrine and paracrine protection of HGF in the injured heart. We also analyse the role of HGF/Met in stem cell maintenance and in stem cell therapies for MI. Finally, we summarize the most significant results on the use of HGF in experimental models of heart injury and discuss the potential of the molecule for treating ischaemic heart disease in humans.
Authors:
V Sala; T Crepaldi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-02-17
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  68     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-20     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1703-17     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Corso Massimo D'Azeglio 52, 10126, Turin, Italy.
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MeSH Terms
Descriptor/Qualifier:
Gene Therapy
Hepatocyte Growth Factor / genetics,  physiology*,  therapeutic use
Humans
Myocardial Infarction / physiopathology,  therapy*
Paracrine Communication
Proto-Oncogene Proteins c-met / genetics,  metabolism,  physiology*
Receptors, Growth Factor / genetics,  metabolism,  physiology*
Stem Cells / cytology,  metabolism
Chemical
Reg. No./Substance:
0/Receptors, Growth Factor; 67256-21-7/Hepatocyte Growth Factor; EC 2.7.10.1/MET protein, human; EC 2.7.10.1/Proto-Oncogene Proteins c-met

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