| Novel therapy for malignant pleural mesothelioma based on anti-energetic effect: an experimental study using 3-Bromopyruvate on nude mice. | |
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MedLine Citation:
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PMID: 19414400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most cancer cells exhibit increased anaerobic glycolysis and use this metabolic pathway for the generation of ATP as a main source of energy. This impaired metabolism of glucose, leading to the secretion of lactic acid even in the presence of oxygen, is named the Warburg effect. Because cancer cells are partly or mainly dependent on such a pathway to generate ATP, inhibition of glycolysis may slow down the proliferation or kill cells. MATERIALS AND METHODS: The effect of 3-Bromopyruvate (3-BrPA) alone or associated to cisplatin on nude mice presenting intraperitoneal carcinomatosis developed after intraperitoneal injection of human mesothelioma cells (MSTO-211H) was investigated. RESULTS: 3-BrPA significantly prolonged survival of animals. Combined with cisplatin, it demonstrated significant benefit on survival whereas cisplatin alone had no or a mild effect. CONCLUSION: 3-BrPA may thus constitute an interesting novel anticancer drug that could be tested in humans. |
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Authors:
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Xiaodong Zhang; Emilie Varin; Mélanie Briand; Stéphane Allouche; Natacha Heutte; Laurent Schwartz; Laurent Poulain; Philippe Icard |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 29 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1443-8 Citation Subset: IM |
Affiliation:
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Anticancer Center Francois BACLESSE, Caen, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cisplatin / pharmacology Energy Metabolism Enzyme Inhibitors / pharmacology* Female Humans Mesothelioma / drug therapy*, pathology Mice Mice, Nude Mitochondria / drug effects, metabolism Oxygen Consumption / drug effects* Peritoneal Neoplasms / drug therapy*, secondary Pleural Neoplasms / drug therapy*, pathology Pyruvate Dehydrogenase Complex / antagonists & inhibitors Pyruvates / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Pyruvate Dehydrogenase Complex; 0/Pyruvates; 1113-59-3/bromopyruvate; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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