Document Detail


Novel therapies for the treatment of inflammatory airway disease.
MedLine Citation:
PMID:  12517250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asthma and chronic obstructive pulmonary disease (COPD) are diseases of the airways with an underlying inflammatory component. The prevalence and healthcare burden of asthma and COPD is still rising and is predicted to continue to rise in the current century. The beta-agonists and corticosteroids form the basis of the treatments available to alleviate the symptoms of asthma, whereas the treatments available for COPD have been shown to have a limited effect on slowing the progression of the disease. Asthma and COPD are both in need of novel, safe treatments to tackle the underlying inflammation that characterises their pathology. The inflammatory processes inherent in asthma and COPD provide the opportunity for innovative drug research. This review will outline the new approaches and targets being investigated, which may provide opportunities for novel therapeutic interventions in these debilitating diseases.
Authors:
David J Hele; Maria G Belvisi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  12     ISSN:  1354-3784     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-08     Completed Date:  2003-03-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-18     Citation Subset:  IM    
Affiliation:
Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart & Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London, SW3 6LY, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Asthmatic Agents / therapeutic use
Anti-Inflammatory Agents / therapeutic use*
Asthma / drug therapy*,  pathology
Cytokines / antagonists & inhibitors
Humans
Inflammation / drug therapy,  pathology
Inflammation Mediators / antagonists & inhibitors
Pulmonary Disease, Chronic Obstructive / drug therapy*,  pathology
Technology, Pharmaceutical / methods,  trends
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Cytokines; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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