Document Detail


Novel therapeutic strategies to counter Pseudomonas aeruginosa infections.
MedLine Citation:
PMID:  22339195     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective biofilm therefore reducing the efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics are under investigation such as those directed against biofilm formation and quorum-sensing systems along with bacteriophages and immunotherapies. Recent advances in next-generation sequencing and comparative genomics have opened the door to a new wave of smart drug design that could revolutionize P. aeruginosa treatment options.
Authors:
Joanne L Fothergill; Craig Winstanley; Chloe E James
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of anti-infective therapy     Volume:  10     ISSN:  1744-8336     ISO Abbreviation:  Expert Rev Anti Infect Ther     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181284     Medline TA:  Expert Rev Anti Infect Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-35     Citation Subset:  IM    
Affiliation:
NIHR Biomedical Research Centre in Microbial Disease, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK.
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