| Novel therapeutic strategies to counter Pseudomonas aeruginosa infections. | |
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MedLine Citation:
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PMID: 22339195 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective biofilm therefore reducing the efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics are under investigation such as those directed against biofilm formation and quorum-sensing systems along with bacteriophages and immunotherapies. Recent advances in next-generation sequencing and comparative genomics have opened the door to a new wave of smart drug design that could revolutionize P. aeruginosa treatment options. |
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Authors:
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Joanne L Fothergill; Craig Winstanley; Chloe E James |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of anti-infective therapy Volume: 10 ISSN: 1744-8336 ISO Abbreviation: Expert Rev Anti Infect Ther Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181284 Medline TA: Expert Rev Anti Infect Ther Country: England |
Other Details:
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Languages: eng Pagination: 219-35 Citation Subset: IM |
Affiliation:
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NIHR Biomedical Research Centre in Microbial Disease, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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