Document Detail

Novel therapeutic strategies for large vessel vasculitis.
MedLine Citation:
PMID:  16504829     Owner:  NLM     Status:  MEDLINE    
Giant cell arteritis and Takayasu's arteritis are systemic vasculitides that cause inflammation of large arteries and their branches. Both have similar histology, but differ in their age of onset. Corticosteroids have been the mainstay of treatment for the past 50 years but are limited by the potential toxicity that may occur in almost 60% of patients. This limitation has lead to the investigation of alternative agents for the treatment of these diseases.
Curry L Koening; Carol A Langford
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  32     ISSN:  0889-857X     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-86, xi     Citation Subset:  IM    
Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Giant Cell Arteritis / therapy*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Immunologic Factors / therapeutic use
Immunosuppressive Agents / therapeutic use
Platelet Aggregation Inhibitors / therapeutic use
Takayasu Arteritis / therapy*
Vascular Surgical Procedures
Grant Support
1 U54 RR019497-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Immunologic Factors; 0/Immunosuppressive Agents; 0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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