Document Detail


Novel technology for modulating locomotor activity as an operant response in the mouse: implications for neuroscience studies involving "exercise" in rodents.
MedLine Citation:
PMID:  23164960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a novel, low-cost device designed to monitor and modulate locomotor activity in murine subjects. This technology has immediate application to the study of effects of physical exercise on various neurobiological endpoints, and will also likely be useful in the study of psychomotor sensitization and drug addiction. Here we demonstrate the capacity of these devices to establish locomotor activity as an operant response reinforced by food pellet presentations, and show that schedules of reinforcement can reliably control this behavior. Importantly, these data show that varying degrees of increased locomotor activity (in other words, "exercise") can be elicited and maintained in mice by manipulating the schedule of reinforcement. Our findings argue that the present technology might reduce the imposition of stress and motivational bias inherent in more traditional procedures for establishing exercise in laboratory rodents, while allowing for true random assignment to experimental groups. As interest in physical exercise as a modulating factor in numerous clinical conditions continues to grow, technologies like the one proposed here are likely to become critical in conducting future experiments along these lines.
Authors:
William E Fantegrossi; Wendy R Xiao; Sarah M Zimmerman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-16
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  212     ISSN:  1872-678X     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-29     Revised Date:  2014-01-31    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / physiology*
Male
Mice
Motor Activity / physiology*
Physical Conditioning, Animal / instrumentation*,  methods
Grant Support
ID/Acronym/Agency:
P20 RR020146/RR/NCRR NIH HHS; RR020146/RR/NCRR NIH HHS; RR029884/RR/NCRR NIH HHS; UL1 RR029884/RR/NCRR NIH HHS
Comments/Corrections

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