| Novel technique for estimating cerebrovascular permeability demonstrates capsazepine protection following ischemia-reperfusion. | |
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MedLine Citation:
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PMID: 17907014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: There has been some discussion as to whether the pial vasculature behaves in the same way as the blood-brain barrier as a whole. Recent studies have shown that capsazepine protects these vessels from the effects of ischemia-reperfusion. We have now used a new method to examine this protection in the whole brain. METHODS: Horseradish peroxidase concentrations were measured in brain sections and plasma, following starch microsphere induced ischemia, which lasted from 20 to 60 minutes, with 30 minutes reperfusion. The PS product was calculated from the Crone-Renkin equation. RESULTS: Permeability increase, which depended on duration of ischemia, was considerably greater in the pia than the parenchyma. The increase was also greater in tissue surrounding large radial venules of the cortex. Single vessel studies showed that these differences mirror those between small and large pial venules. Capsazepine treatment protected the parenchymal blood-brain barrier by limiting the post-ischemic permeability increase to about one third, but had no effect on the pia or radial vessel permeability. CONCLUSIONS: Permeability has been estimated in tissue sections with good spatial resolution using this new technique, which has demonstrated that the TRPV1 receptor plays an important role in the whole brain, not confined to small pial venules. |
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Authors:
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Victoria Gauden; D-E Hu; T Kurokawa; M H Sarker; P A Fraser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 14 ISSN: 1073-9688 ISO Abbreviation: Microcirculation Publication Date: 2007 Nov-Dec |
Date Detail:
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Created Date: 2008-02-15 Completed Date: 2008-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 767-78 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, King's College London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / drug effects*, metabolism, pathology Brain / blood supply, metabolism, pathology Capillary Permeability / drug effects* Capsaicin / analogs & derivatives*, pharmacology Cerebrovascular Circulation / drug effects Female Male Rats Rats, Wistar Reperfusion Injury / drug therapy*, metabolism, pathology Stroke / drug therapy*, metabolism, pathology TRPV Cation Channels / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/TRPV Cation Channels; 0/Trpv1 protein, rat; 0/capsazepine; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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